RESEARCH OVERVIEW

The precise regulation of gene expression and epigenetic modification maintains health status in the whole life span, from germ cells, embryos to adults. Our group has long-lasting interest in the basic cellular and molecular mechanisms of how the specific phenotype is regulated during development and disease in a genomic context.

Inflammatory memory in adults and offspring

Immunological memory of previous inflammatory or infectious encounters is characterized as a defining property of trained immunity associated with innate immune systems. Tissue resident cell types can develop memory as well. Our group utilizes the high-throughput sequencing technology to investigate how to shape inflammatory memory through epigenetic mechanisms at the chromatin level. Key mechanisms are further explored experimentally.

Developmental origins of disease

Within offspring with significant clinical outcomes, our group utilizes single-cell genomics methods to study the cellular and molecular effects induced by the parental disease or environmental exposure. Single-cell muliti-omics technology is widely applied to explore this field, including transcriptome and epigenome profiles. It involves the development biology and epigenetics knowledge.

Disease-induced immune responses and regulation mechanisms in the disease progression

Our group is interested in the clinical issues, including disease-induced immune responses and microenvironments promoting disease progression. The high-throughput sequencing technology, multi-omics data intergration method, animal models, and other functional experiment are combined to address the related problems.